Cancer cells cheat death by reversing a process which causes normal cells to commit suicide at the end of their natural life, scientists have shown.
They showed cancer cells were able to recover even after exposure to a chemical cocktail which triggers suicide in normal cells.
The ability may help cancer cells to block the effect of [...]

Popularity: 4% [?]

When the data from various studies associating DNA repair genes with cancer risk was combined, few of these variants were truly associated with increased cancer risk, according to a team of investigators from the University of Ioannina School of Medicine in Greece. Of the 241 variants studied, they found two that were statistically significant: XRCC1 [...]

Popularity: 7% [?]

Johns Hopkins scientists identify receptor type that makes cancer cells resistant to therapy, more aggressive
The hormone deprivation therapy that prostate cancer patients often take gives them only a temporary fix, with tumors usually regaining their hold within a couple of years. Now, researchers at Johns Hopkins have discovered critical differences in the hormone receptors on [...]

Popularity: 10% [?]

An extract from grape seeds can destroy cancer cells, US research suggests.
In lab experiments, scientists found that the extract stimulated leukaemia cells to commit suicide.
Within 24 hours, 76% of leukaemia cells exposed to the extract were killed off, while healthy cells were unharmed, Clinical Cancer Research reports.

The study raises the possibility of new cancer treatments, [...]

Popularity: 10% [?]

Dr. Charles Clevenger and colleagues at Northwestern University have uncovered that cyclophilin B may contribute to progression in breast cancer.
The protein cyclophilin B affects cell division, motility, and death, all of which are altered in cancerous cells. To explore the role of cyclophilin B-mediated gene regulation in breast cancer, Dr. Clevenger and colleagues inhibited [...]

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Drug company Hoffman-La Roche is telling doctors prescribing Tarceva to lung cancer patients to closely monitor the liver function of those who recently have taken or who are taking the drug.

The drug Tarceva (erlotinib) is used to treat patients with non-small-cell lung cancer at an advanced stage when chemotherapy has not helped to stop the [...]

Popularity: 11% [?]

On Tuesday, Roche announced that the company filed for expanded European approval of cancer treatment Avastin (bevacizumab) as a second-line therapy for patients with glioblastoma.

In November, Genentech filed for FDA approval of Avastin for the expanded indication. Roche and marketing partner Genentech plan to initiate a Phase III study that will evaluate Avastin with standard [...]

Popularity: 12% [?]

An FDA advisory panel stated Tuesday that drugmakers seeking to tailor the use of cancer drugs to patients with specific genetic profiles may be required to conduct larger clinical studies to obtain sufficient data. The panellists specifically discussed the K-ras gene mutation, which causes Eli Lilly’s and Bristol-Myers Squibb’s Erbitux and Amgen’s Vectibix to be [...]

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The collaboration, initiated in August 2006 between MedImmune and Infinity, was transferred to AstraZeneca following its acquisition of MedImmune in June 2007.

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In documents posted to the FDA website, agency staff indicated that prescribing medications based on a patient’s genetic profile can limit their use to those most likely to reap benefits from the treatments. Regulatory advisers are scheduled to discuss on December 16 whether to recommend that physicians screen patients with colon cancer for a mutation [...]

Popularity: 15% [?]